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Man managing obsessive-compulsive disorder while discussing Prozac, risperidone, and OCD treatment progress
Published June 8, 2026 - 3 min read

Finding the Right OCD Medication Combination

Sometimes it takes a long time to find the right SSRI and augmentation combination for OCD. Looking back, I wish I had returned to medication sooner because the improvement has been significant for me.

OCD had me trapped in endless rituals that consumed hours of my day. While medication has not eliminated my OCD, it has given me back some freedom that I had lost.

I started Prozac (fluoxetine) at 20 mg and gradually worked my way up to 80 mg. As I write this, I am about five weeks into treatment overall and approximately two weeks at the therapeutic dose commonly used for OCD. That means I still have plenty of time before I can fully evaluate how effective the medication will be.

So far, however, I can confidently say that I am doing better with it than I was without it.

My psychiatrist also prescribed an augmentation medication called risperidone. Risperidone is commonly used alongside SSRIs in some OCD patients when additional symptom control is needed. In my case, I feel it has helped reduce the urge to perform compulsions while the Prozac continues building up in my system.

Over the years I have tried several other SSRIs, including Lexapro and Celexa. This is my first experience combining Prozac with an augmentation medication, and so far I have been pleased with the results.

I am not expecting a cure. Even a small reduction in symptoms would be worth it to me. When OCD controls your life, a five percent improvement can feel meaningful. Anything that helps reduce the time spent trapped in rituals is a step forward.

One thing I am particularly grateful for is having a psychiatrist who understands OCD. Living in Vietnam as a foreigner has made finding specialized OCD treatment more difficult than it would be in some Western countries. Fortunately, I found a psychiatrist who listens carefully, stays informed, and takes my concerns seriously.

The biggest challenge I still face is finding Exposure and Response Prevention (ERP) therapy locally. ERP is considered one of the most effective treatments for OCD, but I have not been able to find the type of specialized ERP support I am looking for here in Vietnam. Because of that, I continue to rely heavily on online resources and remote support.

For anyone currently searching for the right medication, my advice is simple: do not give up too quickly.

Finding the right medication can take time. Finding the right combination can take even longer. Some people respond well to the first medication they try, while others may need several attempts before finding something that works.

There are also pharmacogenetic tests available in some countries that may provide information about how your body processes certain medications. While these tests can sometimes be helpful, they are not a guarantee that a medication will work for you. Real-world results still matter more than test results.

Most importantly, give your medication enough time to work before deciding it has failed. OCD treatment often requires patience, particularly at higher therapeutic doses. Many people do not experience the full benefit until they have remained on an effective dose for several weeks.

For now, I am cautiously optimistic. I still have OCD. I still have rituals. I still have difficult days.

But I also have more freedom than I did a few months ago, and that alone makes the process worthwhile.

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